M7GpppN-mRNA hydrolase

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M7GpppN-mRNA hydrolase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

M7GpppN-mRNA hydrolase (EC, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP phosphohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

m7G5'ppp5'-mRNA + H2O m7GDP + 5'-phospho-mRNA

Decapping of mRNA is essential in eukaryotic mRNA turnover.


  1. ^ Xu, J.; Yang, J.Y.; Niu, Q.W.; Chua, N.H. (2006). "Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development". Plant Cell. 18: 3386–3398. doi:10.1105/tpc.106.047605. PMC 1785416Freely accessible. PMID 17158604. 
  2. ^ Lu, G.; Zhang, J.; Li, Y.; Li, Z.; Zhang, N.; Xu, X.; Wang, T.; Guan, Z.; Gao, G.F.; Yan, J. (2011). "hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA". Protein Cell. 2: 64–73. doi:10.1007/s13238-011-1009-2. PMC 4875290Freely accessible. PMID 21337011. 
  3. ^ van Dijk, E.; Cougot, N.; Meyer, S.; Babajko, S.; Wahle, E.; Seraphin, B. (2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". EMBO J. 21: 6915–6924. doi:10.1093/emboj/cdf678. PMC 139098Freely accessible. PMID 12486012. 
  4. ^ Parrish, S.; Resch, W.; Moss, B. (2007). "Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression". Proc. Natl. Acad. Sci. USA. 104: 2139–2144. doi:10.1073/pnas.0611685104. PMC 1793903Freely accessible. PMID 17283339. 
  5. ^ Souliere, M.F.; Perreault, J.P.; Bisaillon, M. (2009). "Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism". Biochem. J. 420: 27–35. doi:10.1042/BJ20082296. PMID 19210265. 
  6. ^ Parrish, S.; Moss, B. (2007). "Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses". J. Virol. 81: 12973–12978. doi:10.1128/JVI.01668-07. PMC 2169080Freely accessible. PMID 17881455. 
  7. ^ Song, M.G.; Li, Y.; Kiledjian, M. (2010). "Multiple mRNA decapping enzymes in mammalian cells". Mol. Cell. 40: 423–432. doi:10.1016/j.molcel.2010.10.010. PMC 2982215Freely accessible. PMID 21070968. 

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