MAD2L2

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MAD2L2
Protein MAD2L2 PDB 3ABD.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV
External IDsMGI: 1919140 HomoloGene: 4624 GeneCards: MAD2L2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MAD2L2
Genomic location for MAD2L2
Band1p36.22Start11,674,480 bp[1]
End11,691,650 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127325
NM_006341

NM_027985
NM_001305420

RefSeq (protein)

NP_001120797
NP_006332

NP_001292349
NP_082261

Location (UCSC)Chr 1: 11.67 – 11.69 MbChr 4: 148.13 – 148.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.[5][6]

Function[edit]

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.[6]

Interactions[edit]

MAD2L2 has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116670 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029003 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
  6. ^ a b "Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)".
  7. ^ Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343. 343 (3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
  8. ^ a b Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (Feb 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. PMID 10660610.
  9. ^ a b Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (Sep 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–51. doi:10.1074/jbc.M102051200. PMID 11485998.

Further reading[edit]