MAGEA1

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MAGEA1
PDB 1w72 EBI.jpg
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMAGEA1, CT1.1, MAGE1, MAGE family member A1
External IDsOMIM: 300016 HomoloGene: 88717 GeneCards: MAGEA1
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for MAGEA1
Genomic location for MAGEA1
BandXq28Start153,179,284 bp[1]
End153,183,880 bp[1]
RNA expression pattern
PBB GE MAGEA1 207325 x at fs.png

PBB GE MAGEA1 210467 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004988

n/a

RefSeq (protein)

NP_004979

n/a

Location (UCSC)Chr X: 153.18 – 153.18 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.[3]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[4]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198681 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID 1840703.
  4. ^ "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)".

Further reading[edit]