MAGOH

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MAGOH
Protein MAGOH PDB 1hl6.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAGOH, MAGOH1, MAGOHA, mago homolog, exon junction complex core component, mago homolog, exon junction complex subunit
External IDsMGI: 1330312 HomoloGene: 1776 GeneCards: MAGOH
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MAGOH
Genomic location for MAGOH
Band1p32.3Start53,226,892 bp[1]
End53,238,610 bp[1]
RNA expression pattern
PBB GE MAGOH 210093 s at fs.png

PBB GE MAGOH 210092 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002370

NM_001282737

RefSeq (protein)

NP_002361

NP_001269666

Location (UCSC)Chr 1: 53.23 – 53.24 MbChr 4: 107.88 – 107.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene.[5][6]

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.[6]

Interactions[edit]

MAGOH has been shown to interact with RBM8A[7][8] and NXF1.[8] In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 (core components of the exon junction complex) form a complex with a novel zinc finger protein, Ranshi, that has a role in oocyte differentiation.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162385 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028609 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zhao XF, Colaizzo-Anas T, Nowak NJ, Shows TB, Elliott RW, Aplan PD (April 1998). "The mammalian homologue of mago nashi encodes a serum-inducible protein". Genomics. 47 (2): 319–22. doi:10.1006/geno.1997.5126. PMID 9479507. 
  6. ^ a b "Entrez Gene: MAGOH mago-nashi homolog, proliferation-associated (Drosophila)". 
  7. ^ Zhao, X F; Nowak N J; Shows T B; Aplan P D (January 2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. UNITED STATES. 63 (1): 145–8. doi:10.1006/geno.1999.6064. ISSN 0888-7543. PMID 10662555. 
  8. ^ a b Kataoka, N; Diem M D; Kim V N; Yong J; Dreyfuss G (November 2001). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex". EMBO J. England. 20 (22): 6424–33. doi:10.1093/emboj/20.22.6424. ISSN 0261-4189. PMC 125744Freely accessible. PMID 11707413. 
  9. ^ Lewandowski JP, Sheehan KB, Bennett PE Jr, Boswell RE (Mar 2010). "Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster". Dev. Biol. 339 (2): 307–19. doi:10.1016/j.ydbio.2009.12.035. 

Further reading[edit]