MAML1

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MAML1
Protein MAML1 PDB 2f8x.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAML1, Mam-1, Mam1, mastermind like transcriptional coactivator 1
External IDs MGI: 1890504 HomoloGene: 8845 GeneCards: MAML1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014757

NM_175334

RefSeq (protein)

NP_055572

NP_780543.2
NP_780543

Location (UCSC) Chr 5: 179.73 – 179.8 Mb Chr 11: 50.26 – 50.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[3][4][5]

Function[edit]

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[5]

Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.

Interactions[edit]

MAML1 has been shown to interact with EP300[6][7] and NOTCH1.[3][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851. 
  4. ^ Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol Cell Biol. 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMC 87094Freely accessible. PMID 11390662. 
  5. ^ a b "Entrez Gene: MAML1 mastermind-like 1 (Drosophila)". 
  6. ^ Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC 134732Freely accessible. PMID 12391150. 
  7. ^ Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317Freely accessible. PMID 12050117. 
  8. ^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662Freely accessible. PMID 12370315. 

Further reading[edit]