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Aliases MAML2, MAM-3, MAM2, MAM3, MLL-mastermind like transcriptional coactivator 2
External IDs GeneCards: MAML2
RNA expression pattern
PBB GE MAML2 gnf1h09633 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 95.98 – 96.34 Mb n/a
PubMed search [1] n/a
View/Edit Human

Mastermind-like protein 2 is a protein that in humans is encoded by the MAML2 gene.[2][3][4]

See also[edit]

Details on the activity of the N-terminal domain of Mastermind-like protein 2 may be found under MamL-1.


  1. ^ "Human PubMed Reference:". 
  2. ^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Oct 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol Cell Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662Freely accessible. PMID 12370315. 
  3. ^ Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (Dec 2002). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". J Biol Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158. 
  4. ^ "Entrez Gene: MAML2 mastermind-like 2 (Drosophila)". 

Further reading[edit]

  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906. 
  • Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.". Nat. Genet. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. 
  • Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.". Exp. Cell Res. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503. 
  • Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.". Genes Chromosomes Cancer. 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701. 
  • Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD (2005). "Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.". EMBO J. 24 (13): 2391–402. doi:10.1038/sj.emboj.7600719. PMC 1173159Freely accessible. PMID 15961999. 
  • Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (2007). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma.". Clin. Cancer Res. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685. 
  • Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G (2007). "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas.". Genes Chromosomes Cancer. 46 (6): 559–63. doi:10.1002/gcc.20440. PMID 17334997. 
  • Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK (2007). "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.". Genes Chromosomes Cancer. 46 (7): 708–15. doi:10.1002/gcc.20458. PMID 17437281. 
  • Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T (2007). "Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23).". Genes Chromosomes Cancer. 46 (9): 813–9. doi:10.1002/gcc.20467. PMID 17551948.