MAP1A

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MAP1A
Identifiers
AliasesMAP1A, MAP1L, MTAP1A, microtubule associated protein 1A
External IDsMGI: 1306776 HomoloGene: 1778 GeneCards: MAP1A
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for MAP1A
Genomic location for MAP1A
Band15q15.3Start43,510,958 bp[1]
End43,531,620 bp[1]
RNA expression pattern
PBB GE MAP1A 203151 at fs.png

PBB GE MAP1A 215384 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002373

NM_001173506
NM_032393

RefSeq (protein)

NP_002364

NP_001166977
NP_115769

Location (UCSC)Chr 15: 43.51 – 43.53 MbChr 2: 121.29 – 121.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene.[5][6][7]

Function[edit]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.[7]

Interactions[edit]

MAP1A has been shown to interact with DISC1.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166963 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027254 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lien LL, Feener CA, Fischbach N, Kunkel LM (Jan 1995). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.  Check date values in: |year= / |date= mismatch (help)
  6. ^ Fukuyama R, Rapoport SI (Sep 1995). "Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15". J. Neurosci. Res. 40 (6): 820–5. doi:10.1002/jnr.490400613. PMID 7629894. 
  7. ^ a b "Entrez Gene: MAP1A microtubule-associated protein 1A". 
  8. ^ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986. 

Further reading[edit]