MAP1B

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MAP1B
Identifiers
Aliases MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B
External IDs MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B
Genetically Related Diseases
attention deficit hyperactivity disorder[1]
RNA expression pattern
PBB GE MAP1B 214577 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005909
NM_032010
NM_001324255

NM_008634

RefSeq (protein)

NP_001311184
NP_005900

NP_001311184
NP_005900
NP_032660.2
NP_032660

Location (UCSC) Chr 5: 72.11 – 72.21 Mb Chr 13: 99.42 – 99.52 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.[4][5]

Function[edit]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.[5]

Interactions[edit]

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[6] and RASSF1.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with MAP1B view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. doi:10.1073/pnas.88.17.7873. PMC 52406Freely accessible. PMID 1881920. 
  5. ^ a b "Entrez Gene: MAP1B microtubule-associated protein 1B". 
  6. ^ Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913. 
  7. ^ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320. 

Further reading[edit]