MAP1LC3A

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MAP1LC3A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, microtubule associated protein 1 light chain 3 alpha
External IDsMGI: 1915661 HomoloGene: 12021 GeneCards: MAP1LC3A
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for MAP1LC3A
Genomic location for MAP1LC3A
Band20q11.22Start34,546,854 bp[1]
End34,560,345 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032514
NM_181509

NM_025735

RefSeq (protein)

NP_115903
NP_852610

NP_080011

Location (UCSC)Chr 20: 34.55 – 34.56 MbChr 2: 155.28 – 155.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.[5][6][7] Two transcript variants encoding different isoforms have been found for this gene.

Function[edit]

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.[7]

MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy.[8]

Regulation[edit]

MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A,[9] which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.[10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101460 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027602 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res. 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088.
  6. ^ Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem. 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.
  7. ^ a b "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha".
  8. ^ Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". Biomed Res Int. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
  9. ^ Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT (August 2010). "Regulation of the autophagy protein LC3 by phosphorylation". J. Cell Biol. 190 (4): 533–9. doi:10.1083/jcb.201002108. PMC 2928022. PMID 20713600.
  10. ^ Shvets E, Fass E, Scherz-Shouval R, Elazar Z (August 2008). "The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes". J. Cell Sci. 121 (Pt 16): 2685–95. doi:10.1242/jcs.026005. PMID 18653543.

Further reading[edit]