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Mitogen-activated protein kinase kinase 3
External IDs OMIM602315 MGI1346868 HomoloGene56430 ChEMBL: 2109 GeneCards: MAP2K3 Gene
EC number
Species Human Mouse
Entrez 5606 26397
Ensembl ENSG00000034152 ENSMUSG00000018932
UniProt P46734 O09110
RefSeq (mRNA) NM_002756 NM_008928
RefSeq (protein) NP_002747 NP_032954
Location (UCSC) Chr 17:
21.28 – 21.32 Mb
Chr 11:
60.93 – 60.95 Mb
PubMed search [1] [2]

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.[1]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.[2]


MAP2K3 has been shown to interact with TAOK2[3] and PLCB2.[4]


  1. ^ Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet 78 (3–4): 301–3. doi:10.1159/000134677. PMID 9465908. 
  2. ^ "Entrez Gene: MAP2K3 mitogen-activated protein kinase kinase 3". 
  3. ^ Chen, Z; Cobb M H (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. (United States) 276 (19): 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. 
  4. ^ Barr, Alastair J; Marjoram Robin; Xu Jing; Snyderman Ralph (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. (United States) 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. ISSN 0006-291X. PMID 12054652. 

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