MAP2K5

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MAP2K5
Protein MAP2K5 PDB 1wi0.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, mitogen-activated protein kinase kinase 5
External IDsOMIM: 602520 MGI: 1346345 HomoloGene: 115933 GeneCards: MAP2K5
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for MAP2K5
Genomic location for MAP2K5
Band15q23Start67,542,703 bp[1]
End67,807,117 bp[1]
RNA expression pattern
PBB GE MAP2K5 210482 x at fs.png

PBB GE MAP2K5 211370 s at fs.png

PBB GE MAP2K5 204756 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206804
NM_002757
NM_145160
NM_145161
NM_145162

NM_011840
NM_001364492
NM_001364493
NM_001364494

RefSeq (protein)

NP_001193733
NP_002748
NP_660143

NP_035970
NP_001351421
NP_001351422
NP_001351423

Location (UCSC)Chr 15: 67.54 – 67.81 MbChr 9: 63.16 – 63.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.[5][6]

Function[edit]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.[6]

Upstream[edit]

This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).

Downstream[edit]

This kinase specifically interacts with and activates MAPK7/ERK5.

Interactions[edit]

MAP2K5 has been shown to interact with MAPK7,[5] MAP3K2,[7] Protein kinase Mζ[8] and MAP3K3.[7][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137764 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058444 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Zhou G, Bao ZQ, Dixon JE (May 1995). "Components of a new human protein kinase signal transduction pathway". The Journal of Biological Chemistry. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.
  6. ^ a b "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5".
  7. ^ a b Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (Feb 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". The Journal of Biological Chemistry. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. PMID 11073940.
  8. ^ Diaz-Meco MT, Moscat J (Feb 2001). "MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling". Molecular and Cellular Biology. 21 (4): 1218–27. doi:10.1128/MCB.21.4.1218-1227.2001. PMC 99575. PMID 11158308.
  9. ^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.

Further reading[edit]