From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein MAP3K2 PDB 2cu1.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases MAP3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
External IDs MGI: 1346873 HomoloGene: 74576 GeneCards: MAP3K2
RNA expression pattern
PBB GE MAP3K2 221695 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 127.3 – 127.39 Mb Chr 18: 32.16 – 32.24 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.[3][4][5]


The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.[5]


MAP3K2 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (Mar 1996). "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase". The Journal of Biological Chemistry. 271 (10): 5361–8. PMID 8621389. doi:10.1074/jbc.271.10.5361. 
  4. ^ Zhao Q, Lee FS (Mar 1999). "Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta". The Journal of Biological Chemistry. 274 (13): 8355–8. PMID 10085062. doi:10.1074/jbc.274.13.8355. 
  5. ^ a b "Entrez Gene: MAP3K2 mitogen-activated protein kinase kinase kinase 2". 
  6. ^ a b Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (Feb 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". The Journal of Biological Chemistry. 276 (7): 5093–100. PMID 11073940. doi:10.1074/jbc.M003719200. 
  7. ^ a b Cheng J, Yang J, Xia Y, Karin M, Su B (Apr 2000). "Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation". Molecular and Cellular Biology. 20 (7): 2334–42. PMC 85399Freely accessible. PMID 10713157. doi:10.1128/mcb.20.7.2334-2342.2000. 
  8. ^ Winsauer G, Resch U, Hofer-Warbinek R, Schichl YM, de Martin R (Nov 2008). "XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2". Cellular Signalling. 20 (11): 2107–12. PMID 18761086. doi:10.1016/j.cellsig.2008.08.004. 

Further reading[edit]