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Aliases MAP4, microtubule associated protein 4
External IDs MGI: 97178 HomoloGene: 1780 GeneCards: MAP4
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MAP4
Genomic location for MAP4
Band 3p21.31 Start 47,850,690 bp[1]
End 48,089,272 bp[1]
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 3: 47.85 – 48.09 Mb Chr 9: 109.93 – 110.08 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.[5]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.[6] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.[7] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.[8] mMAP4 is a muscle-specific isoform.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047849 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032479 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98. ( Pt 1): 27–36. PMID 1905296. 
  6. ^ "Entrez Gene: MAP4 microtubule-associated protein 4". 
  7. ^ Samora, Catarina P.; Mogessie, Binyam; Conway, Leslie; Ross, Jennifer L.; Straube, Anne; McAinsh, Andrew D. (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. 
  8. ^ a b Mogessie, Binyam; Roth, Daniel; Rahil, Zainab; Straube, Anne (21 April 2015). "A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation". eLife. 4. doi:10.7554/eLife.05697. PMC 4423121Freely accessible. PMID 25898002. 
  9. ^ Casey, LM; Lyon, HD; Olmsted, JB (April 2003). "Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization". Cell motility and the cytoskeleton. 54 (4): 317–36. doi:10.1002/cm.10105. PMID 12601693. 

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