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Mitogen-activated protein kinase 12
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAPK12 ; ERK3; ERK6; P38GAMMA; PRKM12; SAPK-3; SAPK3
External IDs OMIM602399 MGI1353438 HomoloGene55705 IUPHAR: 1501 GeneCards: MAPK12 Gene
EC number
Species Human Mouse
Entrez 6300 29857
Ensembl ENSG00000188130 ENSMUSG00000022610
UniProt P53778 O08911
RefSeq (mRNA) NM_002969 NM_013871
RefSeq (protein) NP_002960 NP_038899
Location (UCSC) Chr 22:
50.68 – 50.7 Mb
Chr 15:
89.13 – 89.14 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.[1]


Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.[1]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.