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Protein MAPKAPK2 PDB 1kwp.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2
External IDs MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MAPKAPK2
Genomic location for MAPKAPK2
Band 1q32.1 Start 206,684,944 bp[1]
End 206,734,283 bp[1]
RNA expression pattern
PBB GE MAPKAPK2 215050 x at fs.png

PBB GE MAPKAPK2 201460 at fs.png

PBB GE MAPKAPK2 201461 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 206.68 – 206.73 Mb Chr 1: 131.05 – 131.1 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.[5][6]


This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.[7]

See also[edit]

  • SB 203580, suppresses the activation of MAPKAPK2


MAPKAPK2 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162889 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016528 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (Jun 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochem Biophys Res Commun. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591. 
  6. ^ Stokoe D, Caudwell B, Cohen PT, Cohen P (Feb 1994). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". Biochem J. 296 (Pt 3): 843–9. PMC 1137771Freely accessible. PMID 8280084. 
  7. ^ "Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2". 
  8. ^ a b Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR (Feb 2001). "p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils". J. Biol. Chem. 276 (5): 3517–23. doi:10.1074/jbc.M005953200. PMID 11042204. 
  9. ^ Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". J. Biol. Chem. 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945. 
  10. ^ a b Yannoni YM, Gaestel M, Lin LL (Apr 2004). "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Lett. 564 (1-2): 205–11. doi:10.1016/S0014-5793(04)00351-5. PMID 15094067. 
  11. ^ Dondelinger Y, Delanghe T, Rojas-Rivera D, Priem D, Delvaeye T, Bruggeman I, Van Herreweghe F, Vandenabeele P, Bertrand MJ (October 2017). "MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death". Nature Cell Biology. 19 (10): 1237–1247. doi:10.1038/ncb3608. PMID 28920952. 

Further reading[edit]