MAPKAPK2

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MAPKAPK2
Protein MAPKAPK2 PDB 1kwp.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2
External IDs MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2
RNA expression pattern
PBB GE MAPKAPK2 215050 x at fs.png

PBB GE MAPKAPK2 201460 at fs.png

PBB GE MAPKAPK2 201461 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004759
NM_032960

NM_008551

RefSeq (protein)

NP_004750
NP_116584

NP_032577.1
NP_032577

Location (UCSC) Chr 1: 206.68 – 206.73 Mb Chr 1: 131.05 – 131.1 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.[3][4]

Function[edit]

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.[5]

See also[edit]

  • SB 203580, suppresses the activation of MAPKAPK2

Interactions[edit]

MAPKAPK2 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (Jun 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochem Biophys Res Commun. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591. 
  4. ^ Stokoe D, Caudwell B, Cohen PT, Cohen P (Feb 1994). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". Biochem J. 296 (Pt 3): 843–9. PMC 1137771Freely accessible. PMID 8280084. 
  5. ^ "Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2". 
  6. ^ a b Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR (Feb 2001). "p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils". J. Biol. Chem. 276 (5): 3517–23. doi:10.1074/jbc.M005953200. PMID 11042204. 
  7. ^ Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". J. Biol. Chem. 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945. 
  8. ^ a b Yannoni YM, Gaestel M, Lin LL (Apr 2004). "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Lett. 564 (1-2): 205–11. doi:10.1016/S0014-5793(04)00351-5. PMID 15094067. 

Further reading[edit]