MAPRE1

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MAPRE1
Protein MAPRE1 PDB 1pa7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPRE1, EB1, microtubule associated protein RP/EB family member 1
External IDs MGI: 891995 HomoloGene: 56129 GeneCards: MAPRE1
RNA expression pattern
PBB GE MAPRE1 200712 s at fs.png

PBB GE MAPRE1 200713 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012325

NM_007896

RefSeq (protein)

NP_036457

NP_031922.1
NP_031922

Location (UCSC) Chr 20: 32.82 – 32.85 Mb Chr 2: 153.74 – 153.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene.[3][4][5][6]

Function[edit]

The protein encoded by this gene was first identified by its binding to the APC (Adenomatous polyposis coli) protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.[6]

Interactions[edit]

MAPRE1 has been shown to interact with TERF1.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Aug 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712. 
  4. ^ Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE (Sep 1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. Sci. USA. 95 (18): 10596–601. Bibcode:1998PNAS...9510596B. doi:10.1073/pnas.95.18.10596. PMC 27940Freely accessible. PMID 9724749. 
  5. ^ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. 
  6. ^ a b "Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1". 
  7. ^ Nakamura M, Zhou XZ, Kishi S, Lu KP (Mar 2002). "Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle". FEBS Lett. 514 (2–3): 193–8. doi:10.1016/S0014-5793(02)02363-3. PMID 11943150. 

Further reading[edit]