MAPRE2

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MAPRE2
Identifiers
Aliases MAPRE2, EB1, EB2, RP1, CSCSC2, microtubule associated protein RP/EB family member 2
External IDs HomoloGene: 75027 GeneCards: MAPRE2
RNA expression pattern
PBB GE MAPRE2 202501 at fs.png

PBB GE MAPRE2 213489 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143826
NM_001143827
NM_001256420
NM_014268

n/a

RefSeq (protein)

NP_001137298
NP_001137299
NP_001243349
NP_055083

n/a

Location (UCSC) Chr 18: 34.98 – 35.14 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.[2][3][4]

Function[edit]

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.[4]

Interactions[edit]

MAPRE2 has been shown to interact with APC.[5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. PMID 9233623. 
  3. ^ Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (Dec 2002). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell. 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMC 138635Freely accessible. PMID 12475954. 
  4. ^ a b "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2". 
  5. ^ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712. 
  6. ^ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. 

Further reading[edit]