MARK3

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MARK3
Protein MARK3 PDB 1ul7.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMARK3, CTAK1, KP78, PAR1A, Par-1a, microtubule affinity regulating kinase 3, VIPB
External IDsOMIM: 602678 MGI: 1341865 HomoloGene: 55653 GeneCards: MARK3
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for MARK3
Genomic location for MARK3
Band14q32.32-q32.33Start103,385,392 bp[1]
End103,503,831 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001128918
NM_001128919
NM_001128920
NM_001128921
NM_002376

NM_021516
NM_022801
NM_001370744
NM_001370745

RefSeq (protein)

NP_001122390
NP_001122391
NP_001122392
NP_001122393
NP_002367

NP_067491
NP_073712
NP_001357673
NP_001357674

Location (UCSC)Chr 14: 103.39 – 103.5 MbChr 12: 111.57 – 111.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.[5][6]

Interactions[edit]

MARK3 has been shown to interact with Stratifin.[7][8]

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075413 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007411 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ono T, Kawabe T, Sonta S, Okamoto T (April 1998). "Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 101–2. doi:10.1159/000134692. PMID 9533022.
  6. ^ "Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3".
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. ^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  9. ^ https://www.unige.ch/communication/communiques/2018/cdp180723/

Further reading[edit]