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MAS1 proto-oncogene, G protein-coupled receptor
Symbols MAS1 ; MAS; MGRA
External IDs OMIM165180 MGI96918 HomoloGene1782 IUPHAR: 150 GeneCards: MAS1 Gene
RNA expression pattern
PBB GE MAS1 208210 at tn.png
More reference expression data
Species Human Mouse
Entrez 4142 17171
Ensembl ENSG00000130368 ENSMUSG00000068037
UniProt P04201 P30554
RefSeq (mRNA) NM_002377 NM_008552
RefSeq (protein) NP_002368 NP_032578
Location (UCSC) Chr 6:
159.91 – 159.92 Mb
Chr 17:
12.84 – 12.87 Mb
PubMed search [1] [2]

MAS proto-oncogene, or mas-related G-protein coupled receptor A (MRGA, MRGPRA, MRGPCRA), also proposed as the adenine receptor or P0 receptor, is a protein that in humans is encoded by the MAS1 gene.[1]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[1]

Agonists of the receptor include adenine and 8-aminoadenine.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.