MAS proto-oncogene, or mas-related G-protein coupled receptor A (MRGA, MRGPRA, MRGPCRA), also proposed as the adenine receptor or P0 receptor, is a protein that in humans is encoded by the MAS1gene.
The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". Journal of Cardiovascular Pharmacology. 18 Suppl 2: S7–13. PMID1725048.
Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action". Ciba Foundation Symposium150: 23–38; discussion 38–46. PMID2197067.
Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (Jul 1987). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Research1 (2): 169–78. PMID3329713.
Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (Sep 1988). "The mas oncogene encodes an angiotensin receptor". Nature335 (6189): 437–40. doi:10.1038/335437a0. PMID3419518.
Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (Jun 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID3708691.
Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM (Jul 1996). "The MAS proto-oncogene is not imprinted in humans". Genomics35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID8661154.
Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR (May 2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Experimental Neurology163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID10785460.
Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T (May 2002). "Cell type-specific expression of the Mas proto-oncogene in testis". The Journal of Histochemistry and Cytochemistry50 (5): 691–6. doi:10.1177/002215540205000510. PMID11967280.
Canals M, Jenkins L, Kellett E, Milligan G (Jun 2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". The Journal of Biological Chemistry281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID16611642.