MAS1

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MAS1 proto-oncogene, G protein-coupled receptor
Identifiers
Symbols MAS1 ; MAS; MGRA
External IDs OMIM165180 MGI96918 HomoloGene1782 IUPHAR: 150 GeneCards: MAS1 Gene
RNA expression pattern
PBB GE MAS1 208210 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4142 17171
Ensembl ENSG00000130368 ENSMUSG00000068037
UniProt P04201 P30554
RefSeq (mRNA) NM_002377 NM_008552
RefSeq (protein) NP_002368 NP_032578
Location (UCSC) Chr 6:
159.91 – 159.92 Mb
Chr 17:
12.84 – 12.87 Mb
PubMed search [1] [2]

MAS proto-oncogene, or mas-related G-protein coupled receptor A (MRGA, MRGPRA, MRGPCRA), also proposed as the adenine receptor or P0 receptor, is a protein that in humans is encoded by the MAS1 gene.[1]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[1]

Agonists of the receptor include adenine and 8-aminoadenine.

See also[edit]

References[edit]

Further reading[edit]

  • Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". Journal of Cardiovascular Pharmacology. 18 Suppl 2: S7–13. PMID 1725048. 
  • Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action". Ciba Foundation Symposium 150: 23–38; discussion 38–46. PMID 2197067. 
  • Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (Jul 1987). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Research 1 (2): 169–78. PMID 3329713. 
  • Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (Sep 1988). "The mas oncogene encodes an angiotensin receptor". Nature 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518. 
  • Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (Jun 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. 
  • Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM (Jul 1996). "The MAS proto-oncogene is not imprinted in humans". Genomics 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154. 
  • Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR (May 2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Experimental Neurology 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460. 
  • Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T (May 2002). "Cell type-specific expression of the Mas proto-oncogene in testis". The Journal of Histochemistry and Cytochemistry 50 (5): 691–6. doi:10.1177/002215540205000510. PMID 11967280. 
  • Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (Jul 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792. 
  • Canals M, Jenkins L, Kellett E, Milligan G (Jun 2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". The Journal of Biological Chemistry 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.