MASP1 (protein)

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Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesMASP1, 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF, mannan binding lectin serine peptidase 1, Mannan-binding lectin serine protease 1
External IDsOMIM: 600521 HomoloGene: 89143 GeneCards: MASP1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MASP1
Genomic location for MASP1
Band3q27.3Start187,217,285 bp[1]
End187,292,022 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 187.22 – 187.29 Mbn/a
PubMed search[2]n/a
View/Edit Human

Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene.[3][4][5]

MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 into fragments to form a C3-convertase.[6]


MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.[5]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127241 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Takada F, Takayama Y, Hatsuse H, Kawakami M (Oct 1993). "A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum". Biochemical and Biophysical Research Communications. 196 (2): 1003–9. doi:10.1006/bbrc.1993.2349. PMID 8240317.
  4. ^ Sato T, Endo Y, Matsushita M, Fujita T (Apr 1994). "Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein". International Immunology. 6 (4): 665–9. doi:10.1093/intimm/6.4.665. PMID 8018603.
  5. ^ a b "Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)".
  6. ^ Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T (Sep 2000). "Proteolytic activities of two types of mannose-binding lectin-associated serine protease". Journal of Immunology. 165 (5): 2637–42. doi:10.4049/jimmunol.165.5.2637. PMID 10946292.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.