MCC (gene)

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MCC
Identifiers
Aliases MCC, MCC1, mutated in colorectal cancers
External IDs MGI: 96930 HomoloGene: 20539 GeneCards: MCC
RNA expression pattern
PBB GE MCC 206132 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001085377
NM_002387

NM_001033406
NM_001085373
NM_001085374

RefSeq (protein)

NP_001078846
NP_002378

n/a

Location (UCSC) Chr 5: 113.02 – 113.49 Mb Chr 18: 44.43 – 44.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[3][4]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370. 
  4. ^ a b "Entrez Gene: MCC mutated in colorectal cancers". 

Further reading[edit]