MCM10

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MCM10
Identifiers
AliasesMCM10, CNA43, DNA43, PRO2249, minichromosome maintenance 10 replication initiation factor
External IDsOMIM: 609357 MGI: 1917274 HomoloGene: 41275 GeneCards: MCM10
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for MCM10
Genomic location for MCM10
Band10p13Start13,161,554 bp[1]
End13,211,104 bp[1]
RNA expression pattern
PBB GE MCM10 220651 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018518
NM_182751

NM_027290
NM_001305259

RefSeq (protein)

NP_060988
NP_877428

NP_001292188
NP_081566

Location (UCSC)Chr 10: 13.16 – 13.21 MbChr 2: 4.99 – 5.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.[5][6][7] It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication.[8]

Function[edit]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[7]

Interactions[edit]

MCM10 has been shown to interact with ORC2L.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065328 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026669 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F (Dec 2000). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. 28 (23): 4769–77. doi:10.1093/nar/28.23.4769. PMC 115166. PMID 11095689.
  6. ^ Chattopadhyay S, Bielinsky AK (Sep 2007). "Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication". Mol. Biol. Cell. 18 (10): 4085–95. doi:10.1091/mbc.E06-12-1148. PMC 1995709. PMID 17699597.
  7. ^ a b "Entrez Gene: MCM10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)".
  8. ^ Thu YM, Bielinsky AK (June 2014). "MCM10: one tool for all—Integrity, maintenance and damage control". Seminars in Cell & Developmental Biology. 30: 121–30. doi:10.1016/j.semcdb.2014.03.017. PMC 4043890. PMID 24662891.

Further reading[edit]