MCM10

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
MCM10
Identifiers
Aliases MCM10, CNA43, DNA43, PRO2249, minichromosome maintenance 10 replication initiation factor
External IDs MGI: 1917274 HomoloGene: 41275 GeneCards: MCM10
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for MCM10
Genomic location for MCM10
Band 10p13 Start 13,161,554 bp[1]
End 13,211,104 bp[1]
RNA expression pattern
PBB GE MCM10 220651 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018518
NM_182751

NM_027290
NM_001305259

RefSeq (protein)

NP_060988
NP_877428

NP_001292188
NP_081566

Location (UCSC) Chr 10: 13.16 – 13.21 Mb Chr 2: 4.99 – 5.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.[5][6][7] It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication.[8]

Function[edit]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[7]

Interactions[edit]

MCM10 has been shown to interact with ORC2L.[5]

References[edit]

Further reading[edit]