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Available structures
PDB Ortholog search: PDBe RCSB
Aliases MCM3AP, GANP, MAP80, SAC3, minichromosome maintenance complex component 3 associated protein
External IDs MGI: 1930089 HomoloGene: 2902 GeneCards: MCM3AP
Gene location (Human)
Chromosome 21 (human)
Chr. Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for MCM3AP
Genomic location for MCM3AP
Band No data available Start 46,235,126 bp[1]
End 46,286,297 bp[1]
RNA expression pattern
PBB GE MCM3AP 212269 s at fs.png

PBB GE MCM3AP 215581 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 21: 46.24 – 46.29 Mb Chr 21: 76.47 – 76.52 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.[5][6]


The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.[6]


MCM3AP has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160294 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001150 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Takei Y, Tsujimoto G (September 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. PMID 9712829. doi:10.1074/jbc.273.35.22177. 
  6. ^ a b "Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein". 
  7. ^ Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. PMID 12226073. doi:10.1074/jbc.C200442200. 
  8. ^ Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. PMID 10733502. 
  9. ^ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. PMID 18276110. doi:10.1016/j.cellsig.2008.01.010. 

Further reading[edit]