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Minichromosome maintenance complex component 5
Symbols MCM5 ; CDC46; P1-CDC46
External IDs OMIM602696 MGI103197 HomoloGene4904 GeneCards: MCM5 Gene
EC number
RNA expression pattern
PBB GE MCM5 216237 s at tn.png
PBB GE MCM5 201755 at tn.png
More reference expression data
Species Human Mouse
Entrez 4174 17218
Ensembl ENSG00000100297 ENSMUSG00000005410
UniProt P33992 P49718
RefSeq (mRNA) NM_006739 NM_001302540
RefSeq (protein) NP_006730 NP_001289469
Location (UCSC) Chr 22:
35.4 – 35.43 Mb
Chr 8:
75.11 – 75.13 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.[1][2][3]


The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.[3]

See also[edit]


MCM5 has been shown to interact with:


  1. ^ Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5". Cytogenet Cell Genet 73 (4): 317–21. doi:10.1159/000134366. PMID 8751386. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ a b "Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)". 
  4. ^ a b c d e f Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. 
  5. ^ a b c d DaFonseca CJ, Shu F, Zhang JJ (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027. 
  6. ^ Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751. 
  7. ^ Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R et al. (Dec 1998). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502. 

Further reading[edit]