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Minichromosome maintenance complex component 5
Symbols MCM5 ; CDC46; P1-CDC46
External IDs OMIM602696 MGI103197 HomoloGene4904 GeneCards: MCM5 Gene
EC number
RNA expression pattern
PBB GE MCM5 216237 s at tn.png
PBB GE MCM5 201755 at tn.png
More reference expression data
Species Human Mouse
Entrez 4174 17218
Ensembl ENSG00000100297 ENSMUSG00000005410
UniProt P33992 P49718
RefSeq (mRNA) NM_006739 NM_001302540
RefSeq (protein) NP_006730 NP_001289469
Location (UCSC) Chr 22:
35.4 – 35.43 Mb
Chr 8:
75.11 – 75.13 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.[1][2][3]


The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.[3]

See also[edit]


MCM5 has been shown to interact with:


  1. ^ Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5". Cytogenet Cell Genet 73 (4): 317–21. doi:10.1159/000134366. PMID 8751386. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ a b "Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)". 
  4. ^ a b c d e f Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. 
  5. ^ a b c d DaFonseca CJ, Shu F, Zhang JJ (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027. 
  6. ^ Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751. 
  7. ^ Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, Darnell JE (Dec 1998). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502. 

Further reading[edit]