MCOLN2

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MCOLN2
Identifiers
AliasesMCOLN2, TRP-ML2, TRPML2, mucolipin 2
External IDsMGI: 1915529 HomoloGene: 12258 GeneCards: MCOLN2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MCOLN2
Genomic location for MCOLN2
Band1p22.3Start84,925,583 bp[1]
End84,997,113 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153259
NM_001330647

NM_001005846
NM_026656

RefSeq (protein)

NP_001317576
NP_694991

NP_001005846
NP_080932

Location (UCSC)Chr 1: 84.93 – 85 MbChr 3: 146.15 – 146.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.[5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.[6]

See also[edit]

  • transient receptor potential cation channel, mucolipin subfamily, member 1 (MCOLN1)
  • transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)
  • TRPML

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153898 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011008 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  6. ^ Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. 

External links[edit]