MCRS1

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MCRS1
Identifiers
Aliases MCRS1, ICP22BP, INO80Q, MCRS2, MSP58, P78, microspherule protein 1
External IDs MGI: 1858420 HomoloGene: 4622 GeneCards: MCRS1
RNA expression pattern
PBB GE MCRS1 202556 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012300
NM_001278341
NM_006337

NM_001164156
NM_016766

RefSeq (protein)

NP_001012300
NP_001265270
NP_006328

NP_001157628.1
NP_058046.2
NP_001157628
NP_058046

Location (UCSC) Chr 12: 49.56 – 49.57 Mb Chr 15: 99.24 – 99.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.[3][4][5]

Interactions[edit]

MCRS1 has been shown to interact with PHC2,[6] Death associated protein 6,[7] NOL1,[4] PINX1[8] and Telomerase reverse transcriptase.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bruni R, Roizman B (Nov 1998). "Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells". Journal of Virology. 72 (11): 8525–31. PMC 110262Freely accessible. PMID 9765390. 
  4. ^ a b Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". European Journal of Biochemistry / FEBS. 253 (3): 734–42. doi:10.1046/j.1432-1327.1998.2530734.x. PMID 9654073. 
  5. ^ "Entrez Gene: MCRS1 microspherule protein 1". 
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  7. ^ Lin DY, Shih HM (Jul 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". The Journal of Biological Chemistry. 277 (28): 25446–56. doi:10.1074/jbc.M200633200. PMID 11948183. 
  8. ^ a b Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M (Apr 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochemical and Biophysical Research Communications. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100. 

Further reading[edit]

  • Lin DY, Shih HM (Jul 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". The Journal of Biological Chemistry. 277 (28): 25446–56. doi:10.1074/jbc.M200633200. PMID 11948183. 
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
  • Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M (Apr 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochemical and Biophysical Research Communications. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100. 
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147Freely accessible. PMID 15231747. 
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 
  • Shimono K, Shimono Y, Shimokata K, Ishiguro N, Takahashi M (Nov 2005). "Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription". The Journal of Biological Chemistry. 280 (47): 39436–47. doi:10.1074/jbc.M507356200. PMID 16186106. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Hirohashi Y, Wang Q, Liu Q, Du X, Zhang H, Sato N, Greene MI (Aug 2006). "p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability". Oncogene. 25 (35): 4937–46. doi:10.1038/sj.onc.1209500. PMID 16547491. 
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365Freely accessible. PMID 16565220. 
  • Davidovic L, Bechara E, Gravel M, Jaglin XH, Tremblay S, Sik A, Bardoni B, Khandjian EW (May 2006). "The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons". Human Molecular Genetics. 15 (9): 1525–38. doi:10.1093/hmg/ddl074. PMID 16571602. 
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Zhang J, Liu J, Li X, Li F, Wang L, Zhang J, Liu X, Shen L, Liu N, Deng Y, Yang A, Han H, Zhao M, Yao L (Jan 2007). "The physical and functional interaction of NDRG2 with MSP58 in cells". Biochemical and Biophysical Research Communications. 352 (1): 6–11. doi:10.1016/j.bbrc.2006.10.141. PMID 17109818. 
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931.