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MAM domain containing glycosylphosphatidylinositol anchor 2
Alt. symbolsMAMDC1
Other data
LocusChr. 14 q21.2

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]

There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]


  1. ^ "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08.
  2. ^ "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.
  3. ^ Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943.
  4. ^ "SNP linked to Gene MDGA2". NCBI.
  5. ^ van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D (September 2008). "18762592". Archives of General Psychiatry. 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.
  6. ^ Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning. "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892.