MED16

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MED16
Identifiers
Aliases MED16, DRIP92, THRAP5, TRAP95, mediator complex subunit 16
External IDs MGI: 2158394 HomoloGene: 64602 GeneCards: MED16
RNA expression pattern
PBB GE THRAP5 43544 at fs.png

PBB GE THRAP5 221544 s at fs.png

PBB GE THRAP5 221418 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005481

NM_001163276
NM_198107

RefSeq (protein)

NP_005472

XP_006513550.1
XP_006513551.1

Location (UCSC) Chr 19: 0.87 – 0.89 Mb Chr 10: 79.89 – 79.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.[3][4][5]


Interactions[edit]

MED16 has been shown to interact with Thyroid hormone receptor alpha,[4] Estrogen receptor alpha[6] and Cyclin-dependent kinase 8.[4][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266. 
  4. ^ a b c Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638. 
  5. ^ "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5". 
  6. ^ a b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401Freely accessible. PMID 11867769. 

Further reading[edit]

External links[edit]