MED30

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MED30
Identifiers
AliasesMED30, MED30S, THRAP6, TRAP25, mediator complex subunit 30
External IDsMGI: 1917040 HomoloGene: 12329 GeneCards: MED30
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MED30
Genomic location for MED30
Band8q24.11Start117,520,713 bp[1]
End117,540,262 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282986
NM_080651
NM_001363182

NM_027212

RefSeq (protein)

NP_001269915
NP_542382
NP_001350111

NP_081488

Location (UCSC)Chr 8: 117.52 – 117.54 MbChr 15: 52.71 – 52.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Med30
Identifiers
SymbolMed30
PfamPF11315
InterProIPR021019

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene.[5] It represents subunit Med30 of the Mediator complex and is metazoan-specific,[6] having no homologues in yeasts.

Interactions[edit]

MED30 has been shown to interact with MED22.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164758 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038622 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6".
  6. ^ Baek HJ, Malik S, Qin J, Roeder RG (Apr 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.
  7. ^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro: IPR021019