MED7

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MED7
Identifiers
Aliases MED7, ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs MGI: 1913463 HomoloGene: 3153 GeneCards: MED7
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MED7
Genomic location for MED7
Band 5q33.3 Start 157,137,412 bp[1]
End 157,159,019 bp[1]
RNA expression pattern
PBB GE CRSP9 204350 s at fs.png

PBB GE CRSP9 204349 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004270
NM_001100816

NM_001104530
NM_001104556
NM_001104557
NM_025426

RefSeq (protein)

NP_001094286
NP_004261

NP_001098000
NP_001098026
NP_001098027
NP_079702

Location (UCSC) Chr 5: 157.14 – 157.16 Mb Chr 11: 46.44 – 46.44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.[5][6]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155868 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020397 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412. 
  6. ^ a b "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa". 

Further reading[edit]