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Protein MEF2D PDB 1c7u.png
AliasesMEF2D, myocyte enhancer factor 2D
External IDsOMIM: 600663 MGI: 99533 HomoloGene: 4327 GeneCards: MEF2D
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MEF2D
Genomic location for MEF2D
Band1q22Start156,463,727 bp[1]
End156,500,779 bp[1]
RNA expression pattern
PBB GE MEF2D 203004 s at fs.png

PBB GE MEF2D 203003 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 156.46 – 156.5 MbChr 3: 88.14 – 88.17 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.[5][6]


MEF2D has been shown to interact with:

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116604 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001419 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. PMID 8269842.
  6. ^ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".
  7. ^ a b Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.
  8. ^ Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–793. doi:10.1126/science.286.5440.790. PMID 10531067.
  9. ^ Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–22567. doi:10.1074/jbc.C000304200. PMID 10825153.
  10. ^ Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
  11. ^ Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.
  12. ^ Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
  13. ^ Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.
  14. ^ Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.

Further reading[edit]

External links[edit]