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Meis homeobox 1
Symbols MEIS1 ; MGC43380
External IDs OMIM601739 MGI104717 HomoloGene135741 GeneCards: MEIS1 Gene
RNA expression pattern
PBB GE MEIS1 204069 at tn.png
More reference expression data
Species Human Mouse
Entrez 4211 17268
Ensembl ENSG00000143995 ENSMUSG00000020160
UniProt O00470 Q60954
RefSeq (mRNA) NM_002398 NM_001193271
RefSeq (protein) NP_002389 NP_001180200
Location (UCSC) Chr 2:
66.43 – 66.57 Mb
Chr 11:
18.88 – 19.02 Mb
PubMed search [1] [2]

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[1][2]


Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[2]


MEIS1 has been shown to interact with PBX1[3][4][5] and HOXA9.[3][6]


  1. ^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology 15 (10): 5434–43. PMC 230793. PMID 7565694. 
  2. ^ a b "Entrez Gene: MEIS1 Meis homeobox 1". 
  3. ^ a b Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. PMC 84099. PMID 10082572. 
  4. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. PMC 84774. PMID 10523646. 
  5. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. PMC 84356. PMID 10373562. 
  6. ^ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. PMC 232497. PMID 9343407. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.