MEIS1

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MEIS1
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MEIS1, Meis homeobox 1
External IDs HomoloGene: 135741 GeneCards: MEIS1
RNA expression pattern
PBB GE MEIS1 204069 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002398

n/a

RefSeq (protein)

NP_002389

n/a

Location (UCSC) Chr 2: 66.43 – 66.57 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[2][3]

Function[edit]

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[3]

Interactions[edit]

MEIS1 has been shown to interact with PBX1[4][5][6] and HOXA9.[4][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. PMC 230793Freely accessible. PMID 7565694. 
  3. ^ a b "Entrez Gene: MEIS1 Meis homeobox 1". 
  4. ^ a b Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099Freely accessible. PMID 10082572. 
  5. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. PMC 84774Freely accessible. PMID 10523646. 
  6. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. PMC 84356Freely accessible. PMID 10373562. 
  7. ^ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. PMC 232497Freely accessible. PMID 9343407. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.