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Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesMEIS1, Meis homeobox 1
External IDsOMIM: 601739 HomoloGene: 135741 GeneCards: MEIS1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MEIS1
Genomic location for MEIS1
Band2p14Start66,433,452 bp[1]
End66,573,869 bp[1]
RNA expression pattern
PBB GE MEIS1 204069 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 66.43 – 66.57 Mbn/a
PubMed search[2]n/a
View/Edit Human

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[3][4]


Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[4]


MEIS1 has been shown to interact with PBX1[5][6][7] and HOXA9.[5][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143995 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. doi:10.1128/mcb.15.10.5434. PMC 230793. PMID 7565694.
  4. ^ a b "Entrez Gene: MEIS1 Meis homeobox 1".
  5. ^ a b Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572.
  6. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. doi:10.1128/mcb.19.11.7577. PMC 84774. PMID 10523646.
  7. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. doi:10.1128/mcb.19.7.5134. PMC 84356. PMID 10373562.
  8. ^ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.