MEP1A

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MEP1A
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MEP1A, PPHA, meprin A subunit alpha
External IDs MGI: 96963 HomoloGene: 31323 GeneCards: MEP1A
RNA expression pattern
PBB GE MEP1A 206000 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005588

NM_008585

RefSeq (protein)

NP_005579

NP_032611.2
NP_032611

Location (UCSC) Chr 6: 46.79 – 46.84 Mb Chr 17: 43.47 – 43.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene.[3][4] The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.[5]

Function[edit]

The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A .

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bond JS, Rojas K, Overhauser J, Zoghbi HY, Jiang W (Jul 1995). "The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively". Genomics. 25 (1): 300–3. doi:10.1016/0888-7543(95)80142-9. PMID 7774936. 
  4. ^ "Entrez Gene: MEP1A meprin A, alpha (PABA peptide hydrolase)". 
  5. ^ Banerjee S, Oneda B, Yap LM, Jewell DP, Matters GL, Fitzpatrick LR, Seibold F, Sterchi EE, Ahmad T, Lottaz D, Bond JS (May 2009). "MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease". Mucosal Immunol. 2 (3): 220–31. doi:10.1038/mi.2009.3. PMC 2670347Freely accessible. PMID 19262505. 

Further reading[edit]