METTL3

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METTL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMETTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hMETTL3
External IDsOMIM: 612472 MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for METTL3
Genomic location for METTL3
Band14q11.2Start21,498,133 bp[1]
End21,511,342 bp[1]
RNA expression pattern
PBB GE METTL3 209265 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019852

NM_019721

RefSeq (protein)

NP_062826

NP_062695

Location (UCSC)Chr 14: 21.5 – 21.51 MbChr 14: 52.29 – 52.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene.[5]

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m6A).[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: METTL3 methyltransferase like 3".

Further reading[edit]