MEX3D

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MEX3D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDsMGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MEX3D
Genomic location for MEX3D
Band19p13.3Start1,554,669 bp[1]
End1,568,058 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001174118
NM_203304

NM_198615

RefSeq (protein)

NP_001167589
NP_976049

NP_941017

Location (UCSC)Chr 19: 1.55 – 1.57 MbChr 10: 80.38 – 80.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[5][6]

Function[edit]

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[6]

Structure[edit]

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181588 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048696 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: mex-3 homolog D (C. elegans)". 
  6. ^ a b c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789. 

Further reading[edit]