MFGE8

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MFGE8
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MFGE8, milk fat globule-EGF factor 8 protein, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47
External IDs MGI: 102768 HomoloGene: 4334 GeneCards: MFGE8
RNA expression pattern
PBB GE MFGE8 210605 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001114614
NM_001310319
NM_001310320
NM_001310321
NM_005928

NM_001045489
NM_008594

RefSeq (protein)

NP_001108086
NP_001297248
NP_001297249
NP_001297250
NP_005919

NP_032620.2
NP_001038954
NP_032620

Location (UCSC) Chr 15: 88.9 – 88.91 Mb Chr 7: 79.13 – 79.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.[3][4]

Species distribution[edit]

Mfge8 is secreted protein found in vertebrates, including mammals as well as birds.

Function[edit]

MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fiber in arteries.[5] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.[6] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.[7] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.[8]

MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein". 
  4. ^ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics. 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496. 
  5. ^ Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, Thelin S, Sletten K, Gerwins P, Westermark P (June 2006). "Lactadherin binds to elastin--a starting point for medin amyloid formation?". Amyloid. 13 (2): 78–85. doi:10.1080/13506120600722530. PMID 16911961. 
  6. ^ Peng S, Glennert J, Westermark P (June 2005). "Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body". Amyloid. 12 (2): 96–102. doi:10.1080/13506120500107006. PMID 16011985. 
  7. ^ Silvestre JS, Théry C, Hamard G, Boddaert J, Aguilar B, Delcayre A, Houbron C, Tamarat R, Blanc-Brude O, Heeneman S, Clergue M, Duriez M, Merval R, Lévy B, Tedgui A, Amigorena S, Mallat Z (May 2005). "Lactadherin promotes VEGF-dependent neovascularization". Nat. Med. 11 (5): 499–506. doi:10.1038/nm1233. PMID 15834428. 
  8. ^ Raymond A, Ensslin MA, Shur BD (April 2009). "SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions". J. Cell. Biochem. 106 (6): 957–66. doi:10.1002/jcb.22076. PMC 2742659Freely accessible. PMID 19204935. 

Further reading[edit]