MFGE8

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
MFGE8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMFGE8, milk fat globule-EGF factor 8 protein, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, milk fat globule EGF and factor V/VIII domain containing
External IDsOMIM: 602281 MGI: 102768 HomoloGene: 4334 GeneCards: MFGE8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001114614
NM_001310319
NM_001310320
NM_001310321
NM_005928

NM_001045489
NM_008594

RefSeq (protein)

NP_001108086
NP_001297248
NP_001297249
NP_001297250
NP_005919

NP_001038954
NP_032620

Location (UCSC)Chr 15: 88.9 – 88.91 MbChr 7: 78.78 – 78.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.[5][6]

Species distribution[edit]

Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds.

Function[edit]

MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fibers in arteries.[7] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.[8] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.[9] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.[10]

MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells.[11] Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140545 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030605 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein".
  6. ^ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics. 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496.
  7. ^ Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, Thelin S, Sletten K, Gerwins P, Westermark P (June 2006). "Lactadherin binds to elastin--a starting point for medin amyloid formation?". Amyloid. 13 (2): 78–85. doi:10.1080/13506120600722530. PMID 16911961. S2CID 22755686.
  8. ^ Peng S, Glennert J, Westermark P (June 2005). "Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body". Amyloid. 12 (2): 96–102. doi:10.1080/13506120500107006. PMID 16011985. S2CID 23351552.
  9. ^ Silvestre JS, Théry C, Hamard G, Boddaert J, Aguilar B, Delcayre A, Houbron C, Tamarat R, Blanc-Brude O, Heeneman S, Clergue M, Duriez M, Merval R, Lévy B, Tedgui A, Amigorena S, Mallat Z (May 2005). "Lactadherin promotes VEGF-dependent neovascularization". Nat. Med. 11 (5): 499–506. doi:10.1038/nm1233. PMID 15834428. S2CID 9154352.
  10. ^ Raymond A, Ensslin MA, Shur BD (April 2009). "SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions". J. Cell. Biochem. 106 (6): 957–66. doi:10.1002/jcb.22076. PMC 2742659. PMID 19204935.
  11. ^ Aguzzi A, Kranich J, Krautler NJ (2014). "Follicular dendritic cells: origin, phenotype, and function in health and disease". Trends in Immunology. 35 (3): 105–113. doi:10.1016/j.it.2013.11.001. PMID 24315719.

Further reading[edit]