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Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Symbols MFI2 ; CD228; MAP97; MTF1; MTf
External IDs OMIM155750 MGI1353421 HomoloGene4335 GeneCards: MFI2 Gene
RNA expression pattern
PBB GE MFI2 220043 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4241 30060
Ensembl ENSG00000163975 ENSMUSG00000022780
UniProt P08582 Q9R0R1
RefSeq (mRNA) NM_005929 NM_013900
RefSeq (protein) NP_005920 NP_038928
Location (UCSC) Chr 3:
196.99 – 197.03 Mb
Chr 16:
31.88 – 31.9 Mb
PubMed search [1] [2]

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[1]


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.