MFSD1

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MFSD1
Identifiers
AliasesMFSD1, SMAP4, major facilitator superfamily domain containing 1
External IDsMGI: 1914118 HomoloGene: 11228 GeneCards: MFSD1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MFSD1
Genomic location for MFSD1
Band3q25.32Start158,732,198 bp[1]
End158,829,719 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167903
NM_001289406
NM_001289407
NM_022736

NM_025813

RefSeq (protein)

NP_001161375
NP_001276335
NP_001276336
NP_073573

NP_080089

Location (UCSC)Chr 3: 158.73 – 158.83 MbChr 3: 67.58 – 67.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan.[5] It is an Atypical solute carrier.[6]

It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes [6] and lysosomes.[7][8]

HGNC:25874

MFSD1 belongs to AMTF6.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118855 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027775 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  6. ^ a b Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
  7. ^ Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi:10.1074/mcp.M112.021980. PMC 3675815. PMID 23436907.
  8. ^ Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi:10.1093/hmg/ddr306. PMID 21752829.
  9. ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.