||This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (November 2015) (Learn how and when to remove this template message)|
|Jmol 3D model||Interactive image|
|Molar mass||475.63 g·mol−1|
|Solubility||100 mM in EtOH and DMSO|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage.