MG132

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MG132
MG132.png
Names
Other names
N-(benzyloxycarbonyl)leucinylleucinylleucinal
Z-Leu-Leu-Leu-al
Identifiers
133407-82-6 YesY
ChemSpider 406728 N
Jmol-3D images Image
PubChem 462382
Properties
C26H41N3O5
Molar mass 475.63 g·mol−1
Appearance white solid
Solubility 100 mM in EtOH and DMSO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage.

References[edit]

http://www.merck-chemicals.com/germany/life-science-research/mg-132/EMD_BIO-474790/p_w_.b.s1LzxMAAAEW02EfVhTm