MGAT4B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MGAT4B
Identifiers
Aliases MGAT4B, GNT-IV, GNT-IVB, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
External IDs MGI: 2143974 HomoloGene: 8611 GeneCards: MGAT4B
RNA expression pattern
PBB GE MGAT4B 220189 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_054013
NM_014275

NM_145926

RefSeq (protein)

NP_055090
NP_463459

NP_666038.3
NP_666038

Location (UCSC) Chr 5: 179.8 – 179.81 Mb Chr 11: 50.21 – 50.24 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT4B gene.[3][4]

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. Therefore the protein is essential for the production of tri- and tetra-antennary sugar chains. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.[4] Its affinities for donors of acceptors are lower than that of MGAT4A so it is suggested that it is not the main contributor in N-glycan biosynthesis.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yoshida A, Minowa MT, Takamatsu S, Hara T, Ikenaga H, Takeuchi M (Jul 1999). "A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment". Glycoconj J. 15 (12): 1115–23. doi:10.1023/A:1006951519522. PMID 10372966. 
  4. ^ a b "Entrez Gene: MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B". 
  5. ^ Q9UQ53

Further reading[edit]