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3D model (JSmol)
|Molar mass||475.63 g·mol−1|
|Solubility||100 mM in EtOH and DMSO|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
MG132 is a potent, reversible, and cell-permeable proteasome inhibitor  (Ki = 4 nM). It belongs to the class of synthetic peptide aldehydes . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage.
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