MHC class I polypeptide-related sequence A

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MICA
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MICA, MIC-A, PERB11.1, MHC class I polypeptide-related sequence A
External IDs GeneCards: MICA
RNA expression pattern
PBB GE MICA 205904 at fs.png

PBB GE MICA 205905 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289154
NM_000247
NM_001177519
NM_001289152
NM_001289153

n/a

RefSeq (protein)

NP_000238
NP_001170990
NP_001276081
NP_001276082
NP_001276083

n/a

Location (UCSC) Chr 6: 31.4 – 31.42 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus.[2] MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.[2] However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do.[3] MICA rather functions as a stress-induced ligand for NKG2D receptor.[4] For example, the heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element.[3] MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ a b Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. PMC 44180Freely accessible. PMID 8022771. doi:10.1073/pnas.91.14.6259. 
  3. ^ a b Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. PMC 38011Freely accessible. PMID 8901601. doi:10.1073/pnas.93.22.12445. 
  4. ^ a b Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. PMID 10426993. doi:10.1126/science.285.5428.727. 

Further reading[edit]