MHC class I polypeptide-related sequence B

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MICB
Protein MICB PDB 1je6.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMICB, PERB11.2, MHC class I polypeptide-related sequence B
External IDsMGI: 2179989 HomoloGene: 88329 GeneCards: MICB
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MICB
Genomic location for MICB
Band6p21.33Start31,494,881 bp[1]
End31,511,124 bp[1]
RNA expression pattern
PBB GE MICB 206247 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289160
NM_001289161
NM_005931

NM_153760
NM_153761

RefSeq (protein)

NP_001276089
NP_001276090
NP_005922

n/a

Location (UCSC)Chr 6: 31.49 – 31.51 MbChr 7: 18.84 – 18.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus.[5] MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.[5] MICB is a stress-induced ligand for NKG2D receptor.[6] The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.[7]

See also[edit]

References[edit]

  1. ^ a b c ENSG00000224378, ENSG00000206449, ENSG00000227772, ENSG00000238289, ENSG00000231372, ENSG00000234218, ENSG00000204516 GRCh38: Ensembl release 89: ENSG00000231179, ENSG00000224378, ENSG00000206449, ENSG00000227772, ENSG00000238289, ENSG00000231372, ENSG00000234218, ENSG00000204516 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040987 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771.
  6. ^ Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.
  7. ^ Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.

Further reading[edit]