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MIPS may refer to:
- Million instructions per second, a measure of a computer's central processing unit performance
- MIPS instruction set, a RISC instruction set family
- Maximum intensity projection, a volume rendering technique
- Multiband Imaging Photometer for Spitzer, an instrument on the Spitzer Space Telescope
- Multi-directional Impact Protection System, a 'slip-plane' technology inside athletic helmets designed to reduce rotational forces that can result from certain impacts
- Maharana Institute of Professional Studies, an institution in Kanpur, Uttar Pradesh, India
- Mansehra International Public School and College, in Mansehra, Pakistan
- Munich Information Center for Protein Sequences, a genomics research center in Germany
- Material input per unit of service, an economic efficiency indicator
- Merit-Based Payment Incentive System, a payment mechanism that provides annual updates to physicians based on performance in multiple categories
- Menards Infiniti Pro Series, a former name of an Indy Pro Series automobile race
- Monthly income preferred stock, a financial instrument
- MIPS, a rabbit in Super Mario 64
- Minimum Ionizing Particles, a term widely used in experimental particle physics.
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