MIR146A

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MIR146A
Identifiers
AliasesMIR146A, MIRN146, MIRN146A, miR-146a, miRNA146A, microRNA 146a
External IDsGeneCards: MIR146A
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MIR146A
Genomic location for MIR146A
Band5q33.3Start160,485,352 bp[1]
End160,485,450 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 5: 160.49 – 160.49 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.[3]

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[3]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000283733 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ a b "Entrez Gene: MicroRNA 146a". Retrieved 2012-01-27.

Further reading[edit]