MIZF

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HINFP
Identifiers
Aliases HINFP, HiNF-P, MIZF, ZNF743, histone H4 transcription factor
External IDs MGI: 2429620 HomoloGene: 9174 GeneCards: HINFP
RNA expression pattern
PBB GE MIZF 206495 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243259
NM_015517
NM_198971

NM_172162

RefSeq (protein)

NP_001230188
NP_056332
NP_945322

NP_751894.2
NP_751894

Location (UCSC) Chr 11: 119.12 – 119.14 Mb Chr 9: 44.29 – 44.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.[3][4]

Function[edit]

MIZF interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.[supplied by OMIM][4]

Interactions[edit]

MIZF has been shown to interact with Methyl-CpG-binding domain protein 2[3] and DHX9.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (Nov 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631. 
  4. ^ a b "Entrez Gene: MIZF MBD2-interacting zinc finger". 
  5. ^ Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A, Nakajima T (Apr 2003). "Antithetic effects of MBD2a on gene regulation". Mol. Cell. Biol. 23 (8): 2645–57. doi:10.1128/MCB.23.8.2645-2657.2003. PMC 152551Freely accessible. PMID 12665568. 

Further reading[edit]