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MK6-83 structure.png
  • 5-methyl-N-[2-(piperidin-1-yl)phenyl]thiophene-2-sulfonamide
CAS Number
PubChem CID
Chemical and physical data
Molar mass336.47 g·mol−1
3D model (JSmol)
  • CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
  • InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3

MK6-83 is a chemical compound which acts as a channel opener for the TRPML family of calcium channels, with moderate selectivity for TRPML1 over the related TRPML2 and TRPML3 subtypes.[1][2][3]

See also[edit]


  1. ^ Kilpatrick BS, Yates E, Grimm C, Schapira AH, Patel S (October 2016). "Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx". Journal of Cell Science. 129 (20): 3859–3867. doi:10.1242/jcs.190322. PMID 27577094.
  2. ^ Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G (April 2019). "Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival". Cancers. 11 (4). doi:10.3390/cancers11040525. PMC 6521337. PMID 31013784.
  3. ^ Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922. doi:10.1016/j.antiviral.2020.104922. PMID 32858116.