Jump to content


From Wikipedia, the free encyclopedia
  • 5-(2,6-dichlorophenyl)-3-oxa-4-azatricyclo[,6]dec-4-ene
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass282.16 g·mol−1
3D model (JSmol)
  • Clc4cccc(Cl)c4C3=NOC2C1CC(CC1)C23
  • InChI=1S/C14H13Cl2NO/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14H,4-6H2

ML2-SA1 (EVP-22) is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML2 calcium channel, with high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels. It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2 from macrophages and stimulating macrophage migration and endolysosomal trafficking.[1][2]

See also[edit]


  1. ^ Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, et al. (November 2018). "Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells". eLife. 7. doi:10.7554/eLife.39720. PMC 6257821. PMID 30479274.
  2. ^ Chen CC, Krogsaeter E, Butz ES, Li Y, Puertollano R, Wahl-Schott C, et al. (November 2020). "TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles". Science Advances. 6 (46): eabb5064. Bibcode:2020SciA....6.5064C. doi:10.1126/sciadv.abb5064. PMC 7673730. PMID 33177082.