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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MLLT3 ; AF9; YEATS3
External IDs OMIM159558 MGI1917372 HomoloGene37933 GeneCards: MLLT3 Gene
RNA expression pattern
PBB GE MLLT3 204918 s at tn.png
PBB GE MLLT3 204917 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4300 70122
Ensembl ENSG00000171843 ENSMUSG00000028496
UniProt P42568 A2AM29
RefSeq (mRNA) NM_001286691 NM_001286158
RefSeq (protein) NP_001273620 NP_001273087
Location (UCSC) Chr 9:
20.34 – 20.62 Mb
Chr 4:
87.77 – 88.03 Mb
PubMed search [1] [2]

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.[1][2][3]


MLLT3 has been shown to interact with BCOR.[4]


  1. ^ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A 90 (10): 4631–5. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309. 
  2. ^ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene 8 (11): 3085–92. PMID 8414510. 
  3. ^ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3". 
  4. ^ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene (England) 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190. 

Further reading[edit]