MMP11

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MMP11
Protein MMP11 PDB 1hv5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MMP11, SL-3, ST3, STMY3, matrix metallopeptidase 11
External IDs MGI: 97008 HomoloGene: 38116 GeneCards: MMP11
RNA expression pattern
PBB GE MMP11 203876 s at fs.png

PBB GE MMP11 203878 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005940

NM_008606
NM_001306184

RefSeq (protein)

NP_005931
NP_005931.2

NP_001293113.1
NP_032632.1
NP_001293113
NP_032632

Location (UCSC) Chr 22: 23.77 – 23.78 Mb Chr 10: 75.92 – 75.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.[3][4][5][6]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P (Aug 1992). "Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22". Genomics. 13 (3): 881–3. doi:10.1016/0888-7543(92)90175-R. PMID 1639418. 
  4. ^ Anglard P, Melot T, Guerin E, Thomas G, Basset P (Oct 1995). "Structure and promoter characterization of the human stromelysin-3 gene". J Biol Chem. 270 (35): 20337–44. doi:10.1074/jbc.270.35.20337. PMID 7657606. 
  5. ^ Luo D, Mari B, Stoll I, Anglard P (Jul 2002). "Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase". J Biol Chem. 277 (28): 25527–36. doi:10.1074/jbc.M202494200. PMID 12006591. 
  6. ^ a b "Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3)". 

Further reading[edit]